RECENT PUBLICATIONS:

2009

  • Linh P. Nguyen, Erin L. Hsu, Goutam Chowdhury, Miroslav Dostalek, F. Peter Guengerich, and Christopher A. Bradfield

    • D-Amino Acid Oxidase Generates Agonists of the Aryl Hydrocarbon Receptor from D-Tryptophan
    Chem Res Toxicol, 2009, in press
    http://pubs.acs.org/articlesonrequest/AOR-62WJErM4JXcu9qq8sKVa


  • Manabu Nukaya, Susan Moran, and Christopher A. Bradfield

    • The Role of the Dioxin-responsive Element Cluster between the Cyp1a1 and Cyp1a2 Loci in Aryl Hydrocarbon Receptor Biology
    Proc Natl Acad Sci USA 2009, 106: 4923-4928 [Abstract] [pdf]


  • Manabu Nukaya and Christopher A. Bradfield

    • Conserved Genomic Structure of the Cyp1a1 and Cyp1a2 Loci and Their Dioxin Responsive Elements Cluster
    Biochem Pharmacol 2009, 77: 654-659 [Abstract] [pdf]


2008
  • Maureen K. Bunger, Edward Glover, Susan M. Moran, Jacqueline A. Walisser, Garet P. Lahvis, Erin L. Hsu, and Christopher A. Bradfield

    • Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor
    Toxicol Sci 2008, 106: 83-92 [Abstract] [pdf]


  • Takeshige Kunieda, Tohru Minamino, Kentaro Miura, Taro Katsuno, Kaoru Tateno, Hideyuki Miyauchi, Shuichi Kaneko, Christopher A. Bradfield, Garret A. FitzGerald and Issei Komuro

    • Reduced Nitric Oxide Causes Age-Associated Impairment of Circadian Rhythmicity
    Circ Res 2008, 102: 607-614 [Abstract] [pdf]


  • Bernice C. Lin, Linh P. Nguyen, Jacqueline A. Walisser, and Christopher A. Bradfield

    • A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse
    Mol Pharmacol 2008, 74: 1367-1371 [Abstract] [pdf]


  • Linh P. Nguyen and Christopher A. Bradfield

    • The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
    Chem Res Toxicol 2008, 21: 102-116 [Abstract] [pdf]


  • Adam A. Smith, Aaron Vollrath, Christopher A. Bradfield, Mark Craven

    • Similarity Queries for Temporal Toxicogenomic Expression Profiles
    PLoS Comput Biol 2008, 4(7): e1000116


  • Emily A. Stevens and Christopher A. Bradfield

    • T Cells Hang in the Balance
    Nature 2008, 453: 46-47 [Abstract] [pdf]


  • Elizabeth J. Westgate, Yan Cheng, Dermot F. Reilly, Tom S. Price, Jacqueline A. Walisser, Christopher A. Bradfield and Garret A. FitzGerald

    • Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo
    Circulation 2008, 117: 2087-2095 [Abstract] [pdf]

2007

  • Kevin R. Hayes, Gina M. Zastrow, Manabu Nukaya, Kalyan Pande, Ed Glover, John P. Maufort, Adam L. Liss, Yan Liu, Susan M. Moran, Aaron L. Vollrath, and Christopher A. Bradfield

    • Hepatic Transcriptional Networks Induced by Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
    Chem Res Toxicol 2007, 20: 1573-1581 [Abstract] [pdf]


  • Bernice C. Lin, Ruth Sullivan, Youngsook Lee, Susan Moran, Edward Glover, and Christopher A. Bradfield

    • Deletion of the Aryl Hydrocarbon Receptor-associated Protein 9 Leads to Cardiac Malformation and Embryonic Lethality
    J Biol Chem 2007, 282: 35924-35932 [Abstract] [pdf]


  • Brian J. McMillan and Christopher A. Bradfield

    • The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems
    Mol Pharmacol 2007, 72: 487-498 [Abstract] [pdf]


  • Brian J. McMillan and Christopher A. Bradfield

    • The Aryl Hydrocarbon Receptor Is Activated by Modified Low-Density Lipoprotein
    Proc Natl Acad Sci USA 2007, 104: 1412-1417 [Abstract] [pdf]


  • Brian J. McMillan, Susanne N. McMillan, Ed Glover, and Christopher A. Bradfield

    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Premature Activation of the KLF2 Regulon during Thymocyte Development
    J Biol Chem 2007, 282: 12590-12597 [Abstract] [pdf]

2006

  • Elizabeth E. Dunham, Emily A. Stevens, Edward Glover, and Christopher A. Bradfield

    • The Aryl Hydrocarbon Receptor Signaling Pathway Is Modified through Interactions with a Kelch Protein
    Mol Pharmacol 2006, 70: 8-15 [Abstract] [pdf]


  • Eric B. Harstad, Christopher A. Guite, Tami L. Thomae, and Christopher A. Bradfield

    • Liver Deformation in Ahr-Null Mice: Evidence for Aberrant Hepatic Perfusion in Early Development
    Mol Pharmacol 2006, 69: 1534-1541 [Abstract] [pdf]


  • Erin L. McDearmon, Kush N. Patel, Caroline H. Ko, Jacqueline A. Walisser, Andrew C. Schook, Jason L. Chong, Lisa D. Wilsbacher, Eun J. Song, Hee-Kyung Hong, Christopher A. Bradfield, and Joseph S. Takahashi

    • Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice
    Science 2006, 314: 1304-1308 [Abstract] [pdf]


  • Tami L. Thomae, Emily A. Stevens, Adam L. Liss, Norman R. Drinkwater, and Christopher A. Bradfield

    • The Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Modified by a Locus on Mouse Chromosome 3
    Mol Pharmacol 2006, 69: 770-775 [Abstract] [pdf]


  • Jacqueline A. Walisser and Christopher A. Bradfield

    • A Time to Divide: Does the Circadian Clock Control Cell Cycle?
    Dev Cell 2006, 10: 539-548 [Abstract] [pdf]

2005

  • Maureen K. Bunger, Jacqueline A. Walisser, Ruth Sullivan, Paul A. Manley, Susan M. Moran, Vicki L. Kalscheur, Ricki J. Colman, and Christopher A. Bradfield

    • Progressive Arthropathy in Mice With a Targeted Disruption of the Mop3/Bmal-1 Locus
    Genesis 2005, 41: 122-132 [Abstract] [pdf]


  • Kevin R. Hayes and Christopher A. Bradfield

    • Advances in Toxicogenomics
    Chem Res Toxicol 2005, 18: 403-414 [Abstract] [pdf]


  • Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas, and Christopher A. Bradfield

    • EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information
    Mol Pharmacol 2005, 67: 1360-1368 [Abstract] [pdf]


  • Garet P. Lahvis, Robert W. Pyzalski, Edward Glover, Henry C. Pitot, Matthew K. McElwee, and Christopher A. Bradfield

    • The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse
    Mol Pharmacol 2005, 67: 714-720 [Abstract] [PDF] [Data Supplement]


  • Kalyan Pande, Susan M. Moran, and Christopher A. Bradfield

    • Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like Cytokines
    Mol Pharmacol 2005, 67: 1393-1398 [Abstract] [pdf]


  • Tami L. Thomae, Emily A. Stevens, and Christopher A. Bradfield

    • Transforming Growth Factor-b3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
    J Biol Chem 2005, 280: 12742-12746 [Abstract] [pdf]


  • Jacqueline A. Walisser, Edward Glover, Kalyan Pande, Adam L. Liss, and Christopher A. Bradfield

    • Aryl Hydrocarbon Receptor-dependent Liver Development and Hepatotoxicity Are Mediated by Different Cell Types
    Proc Natl Acad Sci USA 2005, 102: 17858-17863 [Abstract] [pdf]

2004

  • F. Peter Guengerich, Martha V. Martin, W. Andrew McCormick, Linh P. Nguyen, Edward Glover, and Christopher A. Bradfield

    • Aryl Hydrocarbon Receptor Response to Indigoids in Vitro and in Vivo
    Arch Biochem Biophys 2004, 423: 309-316 [Abstract] [PDF]


  • Tami L. Thomae, Edward Glover, and Christopher A. Bradfield

    • A Maternal Ahr Null Genotype Sensitizes Embryos to Chemical Teratogenesis
    J Biol Chem 2004, 279: 30189-30194 [Abstract] [PDF]


  • Jacqueline A. Walisser, Maureen K. Bunger, Edward Glover, and Christopher A. Bradfield

    • Gestational Exposure of Ahr and Arnt Hypomorphs to Dioxin Rescues Vascular Development
    Proc Natl Acad Sci USA 2004, 101: 16677-16682 [Abstract] [PDF]


  • Jacqueline A. Walisser, Maureen K. Bunger, Edward Glover, Eric B. Harstad, and Christopher A. Bradfield

    • Patent Ductus Venosus and Dioxin Resistance in Mice Harboring a Hypomorphic Arnt Allele
    J Biol Chem 2004, 279: 16326-16331 [Abstract] [PDF]


  • Guang Yao, Mark Craven, Norman Drinkwater, and Christopher A. Bradfield

    • Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor
    PLOS Biol 2004, 2: 355-367 [Abstract] [PDF]

2003

  • Mark A. Bittinger, Linh P. Nguyen, and Christopher A. Bradfield

    • Aspartate Aminotransferase Generates Proagonists of the Aryl Hydrocarbon Receptor
    Mol Pharmacol 2003, 64: 550-556 [Abstract] [PDF]


  • Maureen K. Bunger, Susan M. Moran, Edward Glover, Tami L. Thomae, Garet P. Lahvis, Bernice C. Lin, and Christopher A. Bradfield

    • Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity and Abnormal Liver Development in Mice Carrying a Mutation in the Nuclear Localization Sequence of the Aryl Hydrocarbon Receptor
    J Biol Chem 2003, 278: 17767-17774 [Abstract] [PDF]


  • G. Yao, E. B. Harstad, and C. A. Bradfield

    • The Ah receptor
    PAS Proteins: Regulators and Sensors of Development and Physiology (S. Crews, Ed.). Kluwer Academic Publishers, Boston, MA, 2003, pp. 149-182.

2002

  • Russell S. Thomas, Sharron G. Penn, Kevin Holden, Christopher A. Bradfield, and David R. Rank

    • Sequence Variation and Phylogenetic History of the Mouse Ahr Gene
    Pharmacogenetics 2002, 12: 151-163     [Abstract] [PDF]


  • Russell S. Thomas, David R. Rank, Sharron G. Penn, Gina M. Zastrow, Kevin R. Hayes, Tianhua Hu, Kalyan Pande, Mark Lewis, Stevan B. Jovanovich, and Christopher A. Bradfield

    • Application of Genomics to Toxicology Research
    Environ Health Perspect 2002, 110(suppl 6): 919-923 [Abstract] [PDF]

2001

  • Russell S. Thomas, David R. Rank, Sharron G. Penn, Gina M. Zastrow, Kevin R. Hayes, Kalyan Pande, Edward Glover, Tomi Silander, Mark W. Craven, Janardan K. Reddy, Stevan B. Jovanovich, and Christopher A. Bradfield

    • Identification of Toxicologically Predictive Gene Sets Using cDNA Microarrays
    Mol Pharmacol 2001, 60: 1189-1194 [Abstract] [PDF]

2000

  • Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran, Cynthia Clendenin, Laurel A. Radcliffe, John B. Hogenesch, M. Celeste Simon, Joseph S. Takahashi, and Christopher A. Bradfield

    • Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals
    Cell 2000, 103: 1009–1017 [Abstract] [PDF]


  • Yi-Zhong Gu, John B. Hogenesch, and Christopher A. Bradfield

    • THE PAS SUPERFAMILY: Sensors of Environmental and Developmental Signals
    Annu Rev Pharmacol Toxicol 2000, 40: 519-561 [Abstract] [PDF]


  • John B. Hogenesch, Yi-Zhong Gu, Susan M. Moran, Kazuhiro Shimomura, Laurel A. Radcliffe, Joseph S. Takahashi, and Christopher A. Bradfield

    • The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors
    J Neurosci 2000, 20(RC83): 1-5 [Abstract] [PDF]


  • Garet P. Lahvis, Susanne L. Lindell, Russell S. Thomas, Robert S. McCuskey, Christopher Murphy, Edward Glover, Michael Bentz, James Southard, and Christopher A. Bradfield

    • Portosystemic Shunting and Persistent Fetal Vascular Structures in Aryl Hydrocarbon Receptor-deficient Mice
    Proc Natl Acad Sci USA 2000, 97: 10442-10447 [Abstract] [PDF]


  • John J. LaPres, Edward Glover, Elizabeth E. Dunham, Maureen K. Bunger, and Christopher A. Bradfield

    • ARA9 Modifies Agonist Signaling through an Increase in Cytosolic Aryl Hydrocarbon Receptor
    J Biol Chem 2000, 275: 6153-6159 [Abstract] [PDF]

1999

  • William K. Chan, Guang Yao, Yi-Zhong Gu, and Christopher A. Bradfield

    • Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways
    DEMONSTRATION OF COMPETITION AND COMPENSATION
    J Biol Chem 1999, 274: 12115-12123 [Abstract] [PDF]

1998

  • Maureen K. Bunger and Christopher A. Bradfield

    • Generation of Allelic Series in Mice by Gene Targeting
    Methods in Molecular Biology: Cytochrome P450 Protocols (I. R. Phillips and E. A. Shephard, Eds.).
    The Humana Press Inc, New Jersey, 1998, pp. 439-468.


  • Lucy A. Carver and Christopher A. Bradfield

    • Simple Models of Dioxin Action
    Molecular Biology in Toxicology (A. Puga and K. Wallace, Eds.).
    Taylor & Francis, Washington DC, 1998, pp. 355-375.


  • Lucy A. Carver, John J. LaPres, Sanjay Jain, Elizabeth E. Dunham, and Christopher A. Bradfield

    • Characterization of the Ah Receptor-associated Protein, ARA9
    J Biol Chem 1998, 273: 33580-33587 [Abstract] [PDF]


  • Yi-Zhong Gu, Susan M. Moran, John B. Hogenesch, Lukas Wartman, and Christopher A. Bradfield

    • Molecular Characterization and Chromosomal Localization of a Third a-Class Hypoxia Inducible Factor Subunit, HIF3a
    Gene Expres 1998, 7: 205-213 [Abstract]


  • John B. Hogenesch, Yi-Zhong Gu, Sanjay Jain, and Christopher A. Bradfield

    • The Basic-Helix-Loop-Helix-PAS Orphan MOP3 Forms Transcriptionally Active Complexes with Circadian and Hypoxia Factors
    Proc Natl Acad Sci USA 1998, 95: 5474-5479 [Abstract] [PDF]


  • Sanjay Jain, Emin Maltepe, Min M. Lu, Celeste Simon, and Christopher A. Bradfield

    • Expression of ARNT, ARNT2, HIF1a, HIF2a and Ah Receptor mRNAs in the Developing Mouse
    Mech Dev 1998, 73: 117-123 [Abstract] [PDF]


  • Garet P. Lahvis and Christopher A. Bradfield

    • Ahr Null Alleles: Distinctive or Different?
    Biochem Pharmacol 1998, 56: 781-787 [Abstract] [pdf]


  • Jo Anne Powell-Coffman, Christopher A. Bradfield, and William B. Wood

    • Caenorhabditis elegans Orthologs of the Aryl Hydrocarbon Receptor and Its Heterodimerization Partner the Aryl Hydrocarbon Receptor Nuclear Translocator
    Proc Natl Acad Sci USA 1998, 95: 2844-2849 [Abstract] [PDF]

1997

  • Lucy A. Carver and Christopher A. Bradfield

    • Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo
    J Biol Chem 1997, 272: 11452-11456 [Abstract] [PDF]


  • John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, and Christopher A. Bradfield

    • Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway
    J Biol Chem 1997, 272: 8581-8593 [Abstract] [PDF]


  • Gang Luo, Yi-Zhong Gu, Sanjay Jain, William K. Chan, Kristen M. Carr, John B. Hogenesch, and Christopher A. Bradfield

    • Molecular Characterization of the Murine Hif-1a Locus
    Gene Expres 1997, 6: 287-299 [Abstract]


  • Emin Maltepe, Jennifer V. Schmidt, David Baunoch, Christopher A. Bradfield, and M. Celeste Simon

    • Abnormal Angiogenesis and Responses to Glucose and Oxygen Deprivation in Mice Lacking the Protein ARNT
    Nature 1997, 386: 403-407 [Abstract] [PDF]

1996

  • Jennifer V. Schmidt and Christopher A. Bradfield

    • Ah Receptor Signaling Pathways
    Annu Rev Cell Dev Biol 1996, 12: 55-89 [Abstract] [PDF]


  • Jennifer V. Schmidt, Gloria Huei-Ting Su, Janardan K. Reddy, M. Celeste Simon, and Christopher A. Bradfield

    • Characterization of a Murine Ahr Null Allele: Involvement of the Ah Receptor in Hepatic Growth and Development
    Proc Natl Acad Sci USA 1996, 93: 6731-6736 [Abstract] [PDF]

1995

  • Hollie I. Swanson, William K. Chan, and Christopher A. Bradfield

    • DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins
    J Biol Chem 1995, 270: 26292-26302 [Abstract] [PDF]

1994

  • Lucy A. Carver, John B. Hogenesch, and Christopher A. Bradfield

    • Tissue Specific Expression of the Rat Ah-receptor and ARNT mRNAs
    Nucleic Acids Res 1994, 22: 3038-3044 [Abstract] [PDF]


  • Lucy A. Carver, Victoria Jackiw, and Christopher A. Bradfield

    • The 90-kDa Heat Shock Protein Is Essential for Ah Receptor Signaling in a Yeast Expression System
    J Biol Chem 1994, 269: 30109-30112 [Abstract] [PDF]


  • William K. Chan, Ruiyin Chu, Sanjay Jain, Janardan K. Reddy, and Christopher A. Bradfield

    • Baculovirus Expression of the Ah Receptor and Ah Receptor Nuclear Translocator
    J Biol Chem 1994, 269: 26464-26471 [Abstract] [PDF]


  • Sanjay Jain, Kristine M. Dolwick, Jennifer V. Schmidt, and Christopher A. Bradfield

    • Potent Transactivation Domains of the Ah Receptor and the Ah Receptor Nuclear Translocator Map to Their Carboxyl Termini
    J Biol Chem 1994, 269: 31518-31524 [Abstract] [PDF]


  • M. M. Le Beau, L. A. Carver, R. Espinosa III, J. V. Schmidt, and C. A. Bradfield

    • Chromosomal Localization of the Human AHR Locus Encoding the Structural Gene for the Ah Receptor to 7p21->p15
    Cytogenet Cell Genet 1994, 66: 172-176 [Abstract]

1993

  • Kristine M. Dolwick, Jennifer V. Schmidt, Lucy A. Carver, Hollie I. Swanson, and Christopher A. Bradfield

    • Cloning and Expression of a Human Ah Receptor cDNA
    Mol Pharmacol 1993, 44: 911-917 [Abstract] [PDF]


  • Kristine M. Dolwick, Hollie I. Swanson, and Christopher A. Bradfield

    • In vitro Analysis of Ah Receptor Domains Involved in Ligand-activated DNA Recognition
    Proc Natl Acad Sci USA 1993, 90: 8566-8570 [Abstract] [PDF]


  • Jennifer V. Schmidt, Lucy A. Carver, and Christopher A. Bradfield

    • Molecular Characterization of the Murine Ahr Gene
    ORGANIZATION, PROMOTER ANALYSIS, AND CHROMOSOMAL ASSIGNMENT
    J Biol Chem 1993, 268: 22203-22209 [Abstract] [PDF]


  • Hollie I. Swanson and Christopher A. Bradfield

    • The AH-Receptor: Genetics, Structure and Function
    Pharmacogenetics 1993, 3: 213-230 [Abstract]

1992

  • Kristine M. Burbach, Alan Poland, and Christopher A. Bradfield

    • Cloning of the Ah-receptor cDNA Reveals a Distinctive Ligand-activated Transcription Factor
    Proc Natl Acad Sci USA 1992, 89: 8185-8189 [Abstract] [PDF]

1991

  • Leonard F. Bjeldanes, Jin-Young Kim, Karl R. Grose, James C. Bartholomew, and Christopher A. Bradfield

    • Aromatic Hydrocarbon Responsiveness-Receptor Agonists Generated from Indole-3-Carbinol in Vitro and in Vivo: Comparisons with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
    Proc Natl Acad Sci USA 1991, 88: 9543-9547 [Abstract] [PDF]