640 - General Virology--Multiplication of Viruses
Semester I; 3 credits. Crosslisted with Bacteriology 640 and Plant Pathology 640. Lectures on the lifecycles of viruses including their structure and replication strategies. Use of viruses to explore basic eukaryotic molecular biological processes is also emphasized as is virus effects on the host cellular cells.
Prerequisites: Introductory courses in biochemistry, cell biology, genetics and microbiology, or consent of instructor.
Instructors: Paul Ahlquist, Robert Kalejta, and Ben Bimber.
SYLLABUS
GENERAL VIROLOGY - MULTIPLICATION OF VlRUSES
FALL SEMESTER, 2007
Paul Ahlquist 841A Bock Labs; Tel, 263-5916; Email: ahlquist@wisc.edu
Professor Office hours: Monday and Wednesday 2:10-3:00 PM
Robert Kalejta 621 Bock Labs; Tel, 265-5546; Email: rfkalejta@wisc.edu
Asst. Professor Office hours: Monday and Wednesday 2:10-3:00 PM
Ben Bimber 585 Science Dr., Tel, 265-3389; Email: bimber@wisc.edu
Discussion Leader Office hours by email or appointment; Exam review sessions will be arranged
| DATE | TOPIC |
| (Sessions in regular type are by Ahlquist, in italics by Kalejta) | |
Wed., Sept. 5 |
Course Introduction / Why and how we study viruses |
Fri., Sept. 7 |
Viruses in the real world: Ebola |
Mon., Sept. 10 |
Ebola discussion / virus structure and assembly |
Wed., Sept. 12 |
dsRNA viruses |
Fri., Sept. 14 |
dsRNA viruses |
Mon., Sept. 17 |
Picornaviruses |
Wed., Sept. 19 |
Picornaviruses |
Fri., Sept. 21 |
Alphaviruses |
Mon., Sept. 24 |
Alphaviruses |
Wed., Sept. 26 |
Coronaviruses / SARS |
Fri., Sept. 28 |
Exam 1 (100 pts) |
Mon., Oct. 1 |
Retroviruses/HIV |
Wed., Oct. 3 |
Retroviruses/HIV |
Fri., Oct. 5 |
Retroviruses/HIV |
Mon., Oct. 8 |
Retroviruses/HIV |
Wed., Oct. 10 |
Papillomavirus |
Fri., Oct. 12 |
Papillomavirus |
Mon., Oct. 15 |
Adenovirus |
Wed., Oct. 17 |
Adenovirus |
Fri., Oct. 19 |
Herpesviruses |
Mon, Oct. 22 |
Herpesviruses |
Wed, Oct. 24 |
Herpesviruses |
Fri., Oct. 26 |
Exam 2 (100 pts) |
Mon, Oct. 29 |
Rhabdoviruses |
Wed., Oct. 31 |
Rhabdoviruses |
Fri., Nov. 2 |
Orthomyxoviruses |
Mon., Nov. 5 |
Orthomyxoviruses |
Wed., Nov. 7 |
Orthomyxoviruses |
Fri., Nov. 9 |
RNA interference - discovery and mechanisms |
Mon., Nov. 12 |
RNA interference - antiviral effects and viral modulation of RNAi |
Wed., Nov. 14 |
Plant viruses - initiation and spread of infection |
Fri., Nov. 16 |
Plant resistance responses: relation to animal innate immunity |
Mon, Nov. 19 |
Exam 3 (100 pts) |
Wed., Nov. 21 |
Genetic variability in viruses |
Fri., Nov. 23 |
Thanksgiving recess, no class |
Mon. Nov. 26 |
Antiviral Drugs |
Wed., Nov. 28 |
Viral modulation of the cell cycle |
Fri., Nov. 30 |
Intrinsic immunity |
| Mon., Dec. 3 | Innate immunity |
| Wed., Dec. 5 | Innate immunity |
Fri., Dec. 7 |
Adaptive immunity (B. Bimber) |
Mon., Dec. 10 |
Vaccines (B. Bimber) |
Wed., Dec. 12 |
Poxviruses: virus modulation of immunity; virus control by vaccination |
Fri., Dec 14 |
Emerging viruses |
| Mon., Dec 17 | Comprehensive Final Exam (150 points) |
Suggested Texts and References
Principles of Virology: Molecular Biology, Pathogenesis, and Control (Second Edition, 2004)
Flint, S. J., Enquist, L. W., Racaniello, V. R. & Skalka, A. M. ASM Press.
Fields Virology (Fifth Edition, 2007)
Knipe, D. and P. Howley (editors). Lippincott, Williams and Wilkins.
Selected Websites
"All the Virology on the WWW"
http://www.virology.net/
Universal Virus Database of the International Committee on Taxonomy of Viruses
http://www.ncbi.nlm.nih.gov/ICTVdb/index.htm
NCBI Viral Genomes Resource
http://www.ncbi.nlm.nih.gov/genomes/VIRUSES/viruses.html
Virus World - Structures and Images (UW-Madison Institute for Molecular Virology)
http://rhino.bocklabs.wisc.edu/cgi-bin/virusworld/virustable.pl?
Grading
Sample Distribution of Test Scores and Letter Grades in Previous Years
The following grades and scores are listed for illustration only and do not necessarily reflect how grades will be given this year.
|
Year |
% of total course points required for indicated grade |
|||||
|
|
A |
AB |
B |
BC |
C |
D |
Graduate |
2006 |
82 |
78 |
68 |
|
|
|
2005 |
83 |
79 |
68 |
63 |
55 |
||
|
2004 |
83 |
78 |
69 |
66 |
61 |
|
|
2003 |
81 |
79 |
70 |
66 |
64 |
|
|
2002 |
84 |
80 |
68 |
|
55 |
|
|
2001 |
84 |
80 |
70 |
60 |
53 |
|
|
|
|
|
|
|
|
|
Undergrad |
2006 |
79 |
75 |
65 |
|
50 |
40 |
2005 |
81 |
65 |
56 |
||||
|
2004 |
|
74 |
63 |
59 |
53 |
48 |
|
2003 |
75 |
|
68 |
64 |
51 |
|
|
2002 |
81 |
|
68 |
64 |
55 |
|
|
2001 |
82 |
72 |
64 |
56 |
51 |
|
|
|
|
|
|
|
|
|
|
|
Number of students with indicated grade |
|||||
|
|
A |
AB |
B |
BC |
C |
D |
Graduate |
2006 |
5 |
2 |
6 |
|
|
|
2005 |
14 |
5 |
12 |
2 |
|||
|
2004 |
10 |
5 |
10 |
1 |
2 |
|
|
2003 |
10 |
7 |
14 |
7 |
2 |
|
|
2002 |
13 |
13 |
22 |
|
1 |
|
|
2001 |
7 |
1 |
12 |
2 |
1 |
|
|
|
|
|
|
|
|
|
Undergrad |
2006 |
6 |
2 |
5 |
|
5 |
1 |
2005 |
4 |
4 |
2 |
||||
|
2004 |
|
3 |
3 |
1 |
3 |
1 |
|
2003 |
1 |
|
3 |
1 |
3 |
|
|
2002 |
8 |
|
4 |
3 |
4 |
|
|
2001 |
1 |
2 |
3 |
2 |
2 |
|
|
|
|
|
|
|
|
|
