Michael N. Gould, Ph.D.
Kelly H. Clifton Professor of Oncology
B.S., 1969, Zoology, University of
Wisconsin-Madison
M.S., 1973, Radiological Sciences,
University of Wisconsin-Madison
Ph.D., 1977, Radiological Sciences, University
of Wisconsin-Madison
Postdoctoral research: Argonne National
Laboratory
Office: 506B McArdle
Laboratory
Telephone: Office - (608) 263-6615; Lab -
(608) 263-6026
Email: gould@oncology.wisc.edu
Lab Web
Page
Research Interests: Molecular biology of mammary carcinogenesis
Research Description: The focus of Dr. Michael Gould's laboratory is in breast cancer research, including both basic and translational projects. Their major project is in breast cancer genetics. Initially, animal models are being used to look for genetic elements that prevent breast cancer. The human homologs of these elements are then tested as genetic candidates in large breast cancer case-control studies. Candidates showing significant association can serve as risk markers and may also provide a better understanding of the role of modifier genes in breast cancer risk and also provide targets for anti-cancer drug development.
Selected recent publications
Smits, B. M. G., Traun, B. D., Devries, T. L., Tran, A., Samuelson, D., Haag, J. D., and Gould, M. An Insulator Loop Resides between the Synthetically Interacting Elements of the Human/Rat Conserved Breast Cancer Susceptibility Locus MCS5A/Mcs5a. Nucleic Acids Res., 40: 132-147, 2012.
Sharma, D., Smits, B. M. G., Eichelberg, M. R., Meilahn, A. L., Muelbl, M. J., Haag, J. D., and Gould, M. N. Quantification of Epithelial Cell Differentiation in Mammary Glands and Carcinomas from DMBA- and MNU-Exposed Rats. PLoS One, 6(10):e26145, 2011.
Smits, B. M. G., Sharma, D., Samuelson, D. J., Woditschka, S., Mau, B., Haag, J. D., and Gould, M. N. The Non-Protein Coding Breast Cancer Susceptibility Locus Mcs5a Acts in a Non-Mammary Cell-Autonomous Fashion Through the Immune System and Modulates T-Cell Homeostasis and Functions. Breast Cancer Res., 13:R81, 2011.
Veillet, A. L., Haag, J. D., Remfert, J. L., Meilahn, A. L., Samuelson, D. J., and Gould, M. N. Mcs5c: A Mammary Carcinoma Susceptibility Locus Located in a Gene Desert that Associates with Tenascin C Expression. Cancer Prev. Res., 4: 97-106, 2011.
van Boxtel, R., Gould, M. N., Cuppen, E., and Smits, B. M. G. ENU Mutagenesis to Generate Genetically Modified Rat Models. In: I. Anegon (Ed.), Rat Genomics: Methods and Protocols, Methods in Molecular Biology, Vol. 597, pp. 151-167, 2010.
Cotroneo, M. S., Haag, J. D., Stapel, N. R., Waller, J. L., Woditschka, S., and Gould, M. N. Freund’s Vaccine Adjuvant Promotes Her2/Neu Breast Cancer. BMC Cancer, 9:19, 2009.
Gould, M. N. The Utility of Comparative Genetics to Inform Breast Cancer Prevention Strategies. Genetics, 183: 409-412, 2009.
Smits, B. M. G., and Gould, M. N. Gene Targeting in the Rat? Cut It Out! Mol. Interv., 9: 226-229, 2009.
Woditschka, S., Haag, J. D., Sullivan, R., and Gould, M. N. A Short-term Rat Mammary Carcinogenesis Model for the Prevention of Hormonally Responsive and Nonresponsive In situ Carcinomas. Cancer Prev. Res., 2: 153-160, 2009.
Aitman, T. J., Critser, J. K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X. M., Flint, J., Gauguier, D., Geurts, A. M., Gould, M., Harris, P. C., Holmdahl, R., Hubner, N., Izsvák, Z., Jacob, H. J., Kuramoto, T., Kwitek, A. E., Marrone, A., Mashimo, T., Moreno, C., Mullins, J., Mullins, L., Olsson, T., Pravenec, M., Riley, L., Saar, K., Serikawa, T., Shull, J. D., Szpirer, C., Twigger, S. N., Voigt, B., and Worley, K. Progress and Prospects in Rat Genetics: A Community View. Nat. Genet., 40: 516-522, 2008.