# Mstat Software

*Mstat* was developed to help students analyze their data
using nonparametric statistical methods. This program grew out of a graduate
course, "Statistical Problems in Genetics and Molecular Biology," taught
by the Department of Oncology at the University of Wisconsin-Madison
over the last 30 years.

This site will have the latest version of the *Mstat* software package
for Windows, Macintosh OSX, and Linux, available from the
Download
link above. Help
for using *Mstat* is also available.

As in the past, the help files include a copy of the notes for the "Statistical Problems …" course mentioned above. These course notes have been made into a book. Both paperback and ebook versions are available, as detailed on the Help page.

## Mstat 6.1.4 released June 5, 2014

Fixed a problem in the *Which test?* dialog. Yet another
quotes in listbox issue. You should be able to install
using the *Help > Check for updates* menu choice.

## Mstat 6.1.3 released May 9, 2014

Further fixes to eliminate the quotes in listbox problem first
seen in the *Import data* function. You should be able to install
using the *Help > Check for updates* menu choice.

## Mstat 6.1.2 released May 5, 2014

Fix regression in *File > Import data* function. New
installers are available on the
Download page. Alternatively, if you've already installed 6.1.1, choose
*Check for updates* from the *Help* menu to install.

## Mstat 6.1.1 released May 2, 2014

Several minor fixes to *Mstat*, including a bug in the
*Which test?* dialog, extending the *Edit* dialog to allow
use of J notation when editing the contents of a variable, showing
the number of bootstrap trials when estimating median survival by
Kaplan-Meier, and a bug when installing *Mstat* on some
non-English language Windows. A fresh install is required for
this release because of problems updating the program using the
*Help > Check for updates* function related to moving the
*Mstat* website to a new server and an issue when installing
to a protected directory (*e.g.*, "Program Files") on Windows.

## Mstat 6.0.1 released January, 2014

Version 6.0 is a major rewrite of *Mstat*, based on using the
Qt toolkit for
the user interface. The most important consequence of this revision
is that a 64-bit version of *Mstat* is now available for OSX.
In addition, this change improves integration with the operating
system across all three platforms, and eliminates the requirement for Java
on OSX and Linux. The most significant functional change is the inclusion of
methods to adjust p-values and compute false discovery rates in the
case of multiple comparisons. Other additions include the ability
to explicitly set plot sizes through the *Modify plot* dialog
and improved error-checking for user input.

## Mstat 5.5.7 released April, 2013

I've implemented significant improvements in the way that *p*-values
are computed for the Wilcoxon rank sum (WRS) test. First, a much faster
algorithm for computing the exact *p*-value allows doing so over
a much increased range of group sizes, up to a total of 200 observations
(100 per group). The first time an exact *p*-value is computed for
two groups of 100 observations each, it will take about 8 seconds to do
so. Subsequent calls to this function will only take a few milliseconds.
This improved algorithm also allows larger sample sizes in the exact
permutation test used for the case of multiple experiments, allowing, for
example, two experiments with 25 observations per group.
When ties are present, or the sample sizes are larger, an improved method is
used to compute the approximate *p*-value, which is much more
accurate than the standard Normal approximation at small *p*-values.
For details, follow the link.

A bug that resulted in the failure to import the last row for some csv files has also been fixed.