Publications
Czarny MJ, Babcock K, Baus RM, Manoharan H, Pitot HC. Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of Igf2 and deregulation of H19. Mol Carcinog. 2007 Mar 28; [Epub ahead of print] PMID: 17393425 [PubMed - as supplied by publisher] [Abstract]
Strati K, Pitot HC, Lambert PF. Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14152-7. Epub 2006 Sep 7. PMID: 16959885 [PubMed - indexed for MEDLIN] [Abstract]
Ogawa H, Gomi T, Nishizawa M, Hayakawa Y, Endo S, Hayashi K, Ochiai H, Takusagawa F, Pitot HC, Mori H, Sakurai H, Koizumi K, Saiki I, Oda H, Fujishita T, Miwa T, Maruyama M, Kobayashi M. Enzymatic and biochemical properties of a novel human serine dehydratase isoform.Biochim Biophys Acta. 2006 May;1764(5):961-71. Epub 2006 Mar 20.
PMID: 16580895 [PubMed - indexed for MEDLINE] [Abstract]
Xu Y, Pitot HC. A software package to improve image quality and isolation of objects of interest for quantitative stereology studies of rat hepatocarcinogenesis.
Comput Methods Programs Biomed. 2006 Feb 1; [Epub ahead of print]
PMID: 16458389 [PubMed - as supplied by publisher] [Abstract]
Xu YH, Manoharan HT, Pitot HC. CpG analyzer, a Windows-based utility program for investigation of DNA methylation.Biotechniques. 2005 Nov;39(5):656, 658, 660 passim. No abstract available.
PMID: 16315371 [PubMed - in process] [Abstract]
Holsapple MP, Pitot HC, Cohen SH, Boobis AR, Klaunig JE, Pastoor T, Dellarco VL, Dragan YP. Mode of action in relevance of rodent liver tumors to human cancer risk.Toxicol Sci. 2006 Jan;89(1):51-6. Epub 2005 Oct 12.
PMID: 16221960 [PubMed - indexed for MEDLINE] [Abstract]
Fang H, Tong W, Perkins R, Shi L, Hong H, Cao X, Xie Q, Yim SH, Ward JM, Pitot HC, Dragan YP. Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling.BMC Bioinformatics. 2005 Jul 15;6 Suppl 2:S6. PMID: 16026603 [Abstract]
Kashii T, Gomi T, Oya T, Ishii Y, Oda H, Maruyama M, Kobayashi M, Masuda T, Yamazaki M, Nagata T, Tsukada K, Nakajima A, Tatsu K, Mori H, Takusagawa F, Ogawa H, Pitot HC. Some biochemical and histochemical properties of human liver serine dehydratase. Int J Biochem Cell Biol. 2005 Mar;37(3):574-89. PMID: 15618015 [PubMed - in process] [Abstract]
Lahvis GP, Pyzalski RW, Glover E, Pitot HC, McElwee MK, Bradfield CA. The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse.Mol Pharmacol. 2005 Mar;67(3):714-20. Epub 2004 Dec 8. PMID: 15590894 [PubMed - in process] [Abstract]
Xu YH, Lahvis G, Edwards H, Pitot HC. Three-dimensional reconstruction from serial sections in PC-Windows platform by using 3D_Viewer. Comput Methods Programs Biomed. 2004 Nov;76(2):143-54.
PMID: 15451163 [PubMed - in process] [Abstract]
Manoharan H, Babcock K, Pitot HC. Changes in the DNA methylation profile of the rat H19 gene upstream region during development and transgenic hepatocarcinogenesis and its role in the imprinted transcriptional regulation of the H19 gene.
Mol Carcinog. 2004 Sep;41(1):1-16.
PMID: 15352122 [PubMed - in process] [Abstract]
Bilger A, Bennett LM, Carabeo RA, Chiaverotti TA, Dvorak C, Liss KM, Schadewald SA, Pitot HC, Drinkwater NR. A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics. 2004 Jun;167(2):859-66.
PMID: 15238534 [PubMed - in process] [Abstract]
Dragan YP, Sargent LM, Babcock K, Kinunen N, Pitot HC. Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats.
Mol Carcinog. 2004 Jul;40(3):150-9. PMID: 15224347 [PubMed - indexed for MEDLINE] [Abstract]
Tessier CR, Doyle GA, Clark BA, Pitot HC, Ross J. Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res. 2004 Jan 1;64(1):209-14.
PMID: 14729626 [PubMed - indexed for MEDLINE] [Abstract]
Yamada T, Komoto J, Takata Y, Ogawa H, Pitot HC, Takusagawa F. Crystal structure of serine dehydratase from rat liver.
Biochemistry. 2003 Nov 11;42(44):12854-65.
PMID: 14596599 [PubMed - indexed for MEDLINE] [Abstract]
Xu YH, Pitot HC. An improved stereologic method for three-dimensional estimation of particle size distribution from observations in two dimensions and its application.
Comput Methods Programs Biomed. 2003 Sep;72(1):1-20. [Abstract]
Manoharan H, Babcock K, Willi J, Pitot HC. Biallelic expression of the H19 gene during spontaneous hepatocarcinogenesis in the albumin SV40 T antigen transgenic rat.
Mol Carcinog. 2003 Sep;38(1):40-7. [Abstract]
Masuda T, Ogawa H, Matsushima T, Kawamata S, Sasahara M, Kuroda K, Suzuki Y, Takata Y, Yamazaki M, Takusagawa F, Pitot HC.Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
Int J Biochem Cell Biol. 2003 Aug;35(8):1234-47. [Abstract]
Boivin GP, Washington K, Yang K, Ward JM, Pretlow TP, Russell R, Besselsen DG, Godfrey VL, Doetschman T, Dove WF, Pitot HC, Halberg RB, Itzkowitz SH, Groden J, Coffey RJ. Pathology of mouse models of intestinal cancer: consensus report and recommendations.Gastroenterology. 2003 Mar;124(3):762-77. Review. No abstract available.
Cihak A, Pitot HC. Incorporation of label from 5-fluoroorotate into non-ribosomal cytoplasmic RNA in rat liver. FEBS Lett. 1970 Feb 16;6(3):206-208. No abstract available.
Pestana A, Sudilovsky O, Pitot HC. Characterization of a cytoplasmic histone-coenzyme A acetyltransferase.
FEBS Lett. 1971 Nov 15;19(1):83-86. No abstract available.
Pitot HC.Animal models of neoplastic development.Dev Biol (Basel). 2001;106:53-7; discussion 57-9, 143-60.
[Abstract]
Divi RL, Dragan YP, Pitot HC, Poirier MC. Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen. Carcinogenesis. 2001 Oct;22(10):1693-9. [Full text]
Pitot HC: Pathways of progression in hepatocarcinogenesis. Lancet. 2001 Sep 15;358(9285):859-60. Review. No abstract available.
Hall DM, Sattler GL, Sattler CA, Zhang HJ, Oberley LW, Pitot HC, Kregel KC Aging lowers steady-state antioxidant enzyme and stress protein expression in primary hepatocytes. J Gerontol A Biol Sci Med Sci. 2001 Jun;56(6):B259-67. [Abstract]
Ou YC, Conolly RB, Thomas RS, Xu Y, Andersen ME, Chubb LS, Pitot HC, Yang RS: A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res. 2001 Mar 1;61(5):1879-89. [Abstract]
Xu Y, Sattler GL, Edwards H, Pitot HC: Nuclear-labeling index analysis (NLIA), a software package used to perform accurate automation of cell nuclear-labeling index analysis on immunohistochemically stained rat liver samples. Comput Methods Programs Biomed. 2000 Sep 1;63(1):55-70. [Abstract]
Dragan Y, Valdes R, Gomez-Angelats M, Felipe A, Javier Casado F, Pitot H, Pastor-Anglada M.
Selective Loss of Nucleoside Carrier Expression in Rat Hepatocarcinomas. Hepatology. 2000 Aug;32(2):239-246. [Abstract]
Firozi PF, Vulimiri SV, Rajaniemi H, Hemminki K, Dragan Y, Pitot HC, DiGiovanni J, Zhu YH, Li D.
Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months.Chem Biol Interact. 2000 Apr 14;126(1):33-43. [Abstract]
Teeguarden JG, Newton MA, Dragan YP, Pitot HC.
Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.
Mol Carcinog. 2000 May;28(1):51-61 [Abstract]
Teeguarden JG, Dragan Y, Pitot HC.
Hazard assessment of chemical carcinogens: the impact of hormesis.
J Appl Toxicol. 2000 Mar-Apr;20(2):113-20. [Abstract]
Haas MJ, Sattler CA, Dragan YP, Gast WL, Pitot HC.
Multiple polypeptide hormone expression in pancreatic islet cell carcinomas derived from phosphoenolpyruvatecarboxykinase-SV40 T antigen transgenic rats.
Pancreas. 2000 Mar;20(2):206-14. [Abstract]
Hikita H, Vaughan J, Babcock K, Pitot HC
Short-term fasting and the reversal of the stage of promotion in rat hepatocarcinogenesis: role of cell replication, apoptosis, and gene expression.
Toxicol Sci. 1999 Dec;52(2 Suppl):17-23. [Abstract]
Teeguarden JG, Dragan YP, Singh J, Vaughan J, Xu YH, Goldsworthy T, Pitot HC
Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.
Toxicol Sci. 1999 Oct;51(2):211-23. [Abstract]
Gomez-Angelats M, Teeguarden JG, Dragan YP, Pitot HC
Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis.
Mol Carcinog. 1999 Jul;25(3):157-63. [Abstract]
Haas MJ, Dragan YP, Hikita H, Shimel R, Takimoto K, Heath S, Vaughan J, Pitot HC
Transgene expression and repression in transgenic rats bearing the phosphoenolpyruvate carboxykinase-simian virus 40 T antigen or the phosphoenolpyruvate carboxykinase-transforming growth factor-alpha constructs.
Am J Pathol. 1999 Jul;155(1):183-92. [Abstract]
Song S, Pitot HC, Lambert PF
The human papillomavirus type 16 E6 gene alone is sufficient To induce carcinomas in transgenic animals.
J Virol. 1999 Jul;73(7):5887-93. [Abstract]
Xu YH, Pitot HC
Building quantitative stereology data files with scion image, a public domain image processing and analysis software. Comput Methods Programs Biomed. 1999 May;59(2):131-42.
PMID: 10348377; UI: 99276133. [Abstract]
Li D, Wang M, Paul GP, Pitot HC, Dragan Y
Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation.
Nutr Cancer. 1999;33(1):40-5. PMID: 10227042; UI: 99243629. [Abstract]
Ogawa H, Takusagawa F, Wakaki K, Kishi H, Eskandarian MR, Kobayashi M, Date T, Huh NH, Pitot HC
Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis.
J Biol Chem. 1999 Apr 30;274(18):12855-60. PMID: 10212273; UI: 99230316. [Abstract]
Haas MJ, Pitot HC
Glucocorticoids Stimulate CREB Binding to a Cyclic-AMP Response Element in the Rat Serine Dehydratase Gene. Arch Biochem Biophys. 1999 Feb 15;362(2):317-324. PMID: 9989941. [Abstract]
Bulera SJ, Sattler CA, Gast WL, Heath S, Festerling TA, Pitot HC
The mechanism of thioacetamide-induced apoptosis in the L37 albumin-SV40 T-antigen transgenic rat hepatocyte-derived cell line occurs without DNA fragmentation. In Vitro Cell Dev Biol Anim 1998 Oct;34(9):685-93 [Abstract]
O'Regan RM, Cisneros A, England GM, MacGregor JI, Muenzner HD, Assikis VJ, Bilimoria MM, Piette M,
Dragan YP, Pitot HC, Chatterton R, Jordan VC
Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth. IJ Natl Cancer Inst 1998 Oct 21;90(20):1552-8 [Abstract]
Nuwaysir EF, Dragan YP, McCague R, Martin P, Mann J, Jordan VC, Pitot HC
Structure-activity relationships for triphenylethylene antiestrogens on hepatic phase-I and phase-II enzyme expression. Biochem Pharmacol 1998 Aug 1;56(3):321-7 [Abstract]
Steinmetz KL, Pogribny IP, James SJ, Pitot HC
Hypomethylation of the rat glutathione S-transferase pi (GSTP) promoter region isolated from methyl-deficient livers and GSTP-positive liver neoplasms.Carcinogenesis 1998 Aug;19(8):1487-94 [Abstract]
Hikita H, Nuwaysir EF, Vaughan J, Babcock K, Haas MJ, Dragan YP, Pitot HC
The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and geneexpression in rat liver during the promotion stage. Carcinogenesis. 1998 Aug;19(8):1417-25.
PMID: 9744538; UI: 98415787. [Abstract]
Pitot HC.
US pivotal studies of irinotecan in colorectal carcinoma. Oncology (Huntingt). 1998 Aug;12(8 Suppl 6):48-53. [MEDLINE record in process]
PMID: 9726091; UI: 98394154. [Abstract]
Dragan YP, Shimel RJ, Bahnub N, Sattler G, Vaughan JR, Jordan VC, Pitot HC
Effect of chronic administration of mestranol, tamoxifen, and toremifene on hepatic ploidy in rats.
Toxicol Sci. 1998 Jun;43(2):129-38. [MEDLINE record in process]
PMID: 9710954; UI: 98376813. [Abstract]
Teeguarden JG, Dragan YP, Pitot HC
Implications of hormesis on the bioassay and hazard assessment of chemical carcinogens.
Hum Exp Toxicol. 1998 May;17(5):254-8. Review.
PMID: 9663932; UI: 98327065. [Abstract]
Pitot HC.
Hepatocyte death in hepatocarcinogenesis.
Hepatology. 1998 Jul;28(1):1-5. Review. No abstract available.
PMID: 9657088; UI: 98319170.
Xu YH, Dragan YP, Campbell HA, Pitot HC
STEREO: a program on a PC-Windows 95 platform for recording and evaluating quantitative stereologic investigations of multistage hepatocarcinogenesis in rodents.
Comput Methods Programs Biomed. 1998 Apr;56(1):49-63.
PMID: 9617527; UI: 98280521. [Abstract]
Haas MJ, Pitot HC
Characterization of rare p53 mutants from carcinogen-treated albumin-simian virus 40 T-antigen transgenic rats. Mol Carcinog. 1998 Feb;21(2):128-34.
PMID: 9496913; UI: 98156627. [Abstract]
Sargent LM, Dragan YP, Sattler G, Xu YH, Wiley J, Pitot HC
Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms. Cancer Res. 1997 Aug 15;57(16):3451-6.
PMID: 9270012; UI: 97413626. [Abstract]
Bulera SJ, Haas MJ, Sattler CA, Li Y, Pitot HC
Cell lines with heterogeneous phenotypes result from a single isolation of albumin-sv40 T-antigen transgenic rat hepatocytes.
Hepatology. 1997 May;25(5):1192-203.
PMID: 9141438; UI: 97286271. [Abstract]
Li D, Dragan Y, Jordan VC, Wang M, Pitot HC
Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus. Cancer Res. 1997 Apr 15;57(8):1438-41.
PMID: 9108442; UI: 97262028. [Abstract]
Hikita H, Vaughan J, Pitot HC
The effect of two periods of short-term fasting during the promotion stage of hepatocarcinogenesis in rats: the role of apoptosis and cell proliferation.
Carcinogenesis. 1997 Jan;18(1):159-66.
PMID: 9054602; UI: 97207109. [Abstract]
Dragan YP, Campbell HA, Xu XH, Pitot HC
Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats.
Carcinogenesis. 1997 Jan;18(1):149-58.
PMID: 9054601; UI: 97207108. [Abstract]
Dragan YP, Singh J, Pitot HC
Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat. Carcinogenesis. 1996 Sep;17(9):2043-52.
PMID: 8824533; UI: 96421916. [Abstract]
Nuwaysir EF, Daggett DA, Jordan VC, Pitot HC
Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen.
Cancer Res. 1996 Aug 15;56(16):3704-10.
PMID: 8706011; UI: 96328090. [Abstract]
Sargent L, Dragan YP, Babcock K, Wiley J, Klaunig J, Pitot HC
Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression. Cancer Res. 1996 Jul 1;56(13):2992-7.
PMID: 8674053; UI: 96258222. [Abstract]
Sargent L, Dragan Y, Xu YH, Sattler G, Wiley J, Pitot HC
Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat. Cancer Res. 1996 Jul 1;56(13):2985-91.
PMID: 8674052; UI: 96258221. [Abstract]