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Norman R. Drinkwater, Ph.D.

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N. Drinkwater photo Professor of Oncology
Marian A. Messerschmidt Professor in Cancer Research

B.S., 1974, Biochemistry, University of Wisconsin-Madison
Ph.D., 1980, Oncology, University of Wisconsin-Madison
Postdoctoral research: Michigan State University

Office: 6553 Wisconsin Institutes for Medical Research
Office - (608) 262-7992; Lab - (608) 262-8008
Email: drinkwater@oncology.wisc.edu

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Research Interests: Genetics and molecular biology of carcinogenesis

Research Description: Genetic factors can play an important role in determining an individual's risk for developing cancer. We are studying inbred strains of mice that are highly sensitive to tumor induction in specific tissues as a model for understanding the mechanism of action of cancer susceptibility genes. In many cases, these genes also play an important role in regulating the proliferation or differentiation of normal cells. We are currently attempting to determine the molecular identities of several cancer susceptibility genes using a "reverse genetic" approach, based on first mapping the genes and then using this positional information as starting points for molecular cloning.

Selected recent publications


Drinkwater N. Robert G. McKinnell, The Understanding, Prevention and Control of Human Cancer: The Historic Work and Lives of Elizabeth Cavert Miller and James A. Miller (Leiden and Boston: Brill, 2016), pp. xvi, 196, $50, hardback, ISBN: 9789004286795. Med Hist. 2017 Jan;61(1):152-153. doi: 10.1017/mdh.2016.121. PubMed Central PMCID: PMC5206955.


Herzig MC, Zavadil JA, Street K, Hildreth K, Drinkwater NR, Reddick T, Herbert DC, Hanes MA, McMahan CA, Reddick RL, Walter CA. DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status. Cancer Prev Res (Phila). 2016 Mar;9(3):245-52. doi: 10.1158/1940-6207.CAPR-15-0251. PubMed PMID: 26667451; PubMed Central PMCID: PMC4777656.

Shen AL, Moran SA, Glover EA, Drinkwater NR, Swearingen RE, Teixeira LB, Bradfield CA. Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. PLoS One. 2016 Jun 16;11(6):e0157577. doi: 10.1371/journal.pone.0157577. eCollection 2016. PubMed PMID: 27310661; PubMed Central PMCID: PMC4910986.


Kimble J, Bement WM, Chang Q, Cox BL, Drinkwater NR, Gourse RL, Hoskins AA, Huttenlocher A, Kreeger PK, Lambert PF, Mailick MR, Miyamoto S, Moss RL, O'Connor-Giles KM, Roopra A, Saha K, Seidel HS. Strategies from UW-Madison for rescuing biomedical research in the US. Elife. 2015 Jun 30;4:e09305. doi: 10.7554/eLife.09305. PubMed PMID: 26122792; PubMed Central PMCID: PMC4484056.

Oberley CC, Bilger A, Drinkwater NR. Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis. Mol Carcinog. 2015 Oct;54(10):959-70. doi: 10.1002/mc.22165. Epub 2014 May 17. PubMed PMID: 24838184; PubMed Central PMCID: PMC4254363.


Kennedy, G. D., Nukaya, M., Moran, S. M., Glover, E., Weinberg, S., Balbo, S., Hecht, S. S., Pitot, H. C., Drinkwater, N. R., and Bradfield, C. A.  Liver Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Is Dependent on the Aryl Hydrocarbon Receptor and TNF/IL-1 Receptors.  Toxicol. Sci., 140(1): 135-143, 2014.

Liu, Y., Johnson, B. P., Shen, A. L., Walisser, J. A., Krentz, K. J., Moran, S. M., Sullivan, R., Glover, E., Parlow, A. F., Drinkwater, N. R., Schuler, L. A., and Bradfield, C. A.  Loss of BMAL1 in Ovarian Steroidogenic Cells Results in Implantation Failure in Female Mice.  Proc. Natl. Acad. Sci. USA, 111(39): 14295-14300, 2014.


Bilger, A., Poli, E., Schneider, A., Baus, R., and Drinkwater, N.  The Hcs7 Mouse Liver Cancer Modifier Maps to a 3.3 Mb Region Carrying the Strong Candidate Ifi202b.  In:  A. Julianov (Ed.), Liver Tumors, pp. 19-36.  Rijeka, Croatia: Intech, 2012.

Drinkwater, N. R., and Gould, M. N.  The Long Path from QTL to Gene. PLoS Genet., 8(9):e1002975, 2012.

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